In Profile: Wednesday's Visitors, West Ham United
City head into the match sitting third in the Premier League standings, although they have suffered defeat in their last two Premier League outings.
The Hammers, meanwhile, were held to a 1-1 draw by Carlo Ancelotti's Everton at London Stadium on Saturday, following a narrow loss at Sheffield United a week earlier.
The manager
Former Preston North End, Everton, Manchester United, Real Sociedad and Sunderland manager David Moyes returned to West Ham for a second spell in charge at the end of 2019.
After Manuel Pellegrini left the Hammers, following a 2-1 home defeat by Leicester, the Scottish manager signed an 18-month contract at London Stadium.
His first game back in the capital was a 4-0 success over Bournemouth, before a 4-0 win at Gillingham in the Emirates FA Cup, although he has won just one point since.
A 1-0 defeat by Sheffield United at Bramall Lane, a clash which involved last-minute VAR drama denying the visitors an equaliser, was followed by a 1-1 home draw with Everton.
Moyes is an experienced manager who has worked at the game's pinnacle, taking the Manchester United post after 11 successful years at Goodison Park.
He arrived in Merseyside having guided Preston to promotion from the Third Division and settling in the second tier, before sealing Everton a UEFA Champions League qualifying spot in 2004/05.
The Toffees fell in the qualification stages, but finished in the top half for the rest of Moyes' tenure, as well as being beaten FA Cup finalists in 2009, before replacing Sir Alex Ferguson at Old Trafford.
However, Moyes' time at United, which included a Community Shield success, was cut short by disappointing domestic form and the Glasgow-born former defender left the Red Devils in April 2014.
His next move was to Spain to manage La Liga club Real Sociedad in November 2014 and, while form initially improved, Moyes was dismissed a year after taking the post.
Moyes' next job was to replace Sam Allardyce at Sunderland, but his only season in charge at Stadium of Light ended with his first career relegation, as the Black Cats fell into the Championship.
Later that year, his first spell at West Ham began in November, with Moyes inspiring the east London outfit to climb out of the relegation zone and towards safety in the 2017/18 campaign.
Despite leaving at the end of that season, West Ham returned to Moyes in late December 2019, to replace Pellegrini as the Hammers aimed to move away from the bottom three.
The squad
The Hammers have a number of long-serving players including Mark Noble, who has made over 400 appearances for his boyhood side since making his professional debut in 2004.
They also have a wealth of talented attackers including Brazil international Felipe Anderson, Ukraine’s Andriy Yarmolenko and Argentina forward Manuel Lanzini.
In defence, Pablo Zabaleta, who played under former Hammers manager Manuel Pellegrini at Manchester City, provides plenty of experience, as does left-back Aaron Cresswell and Italy defender Angelo Ogbonna.
This summer, West Ham made French striker Sébastien Haller their record signing for a reported fee of £36M, and he has scored five Premier League goals since joining from Bundesliga outfit Eintract Frankfurt.
In addition, midfielder Pablo Fornals, striker Albian Ajeti, defender Gonçalo Cardoso and shot-stopper Roberto were also recruited by the Hammers.
The trophy cabinet
West Ham United have enjoyed success on both the domestic and European front since their formation in 1895.
They have won the FA Cup in 1964, 1975 and 1980, they lifted the Charity Shield (now Community Shield) in 1964 and have won England’s second division on two occasions – in 1958 and 1981.
In 1999, the Hammers won the UEFA Intertoto Cup alongside Juventus and Montpellier, while in 1965, they claimed the European Cup Winners' Cup with a 2-0 success over 1860 Munich.
In front of over 97,000 fans at Wembley Stadium, the late Alan Sealey scored twice in three second-half minutes to win it for his side.
The stadium
West Ham United moved to the London Stadium in 2016, having previously played at Upton Park for over a century.
The 60,000-seater stadium was originally constructed for the 2012 Summer Olympics, serving as a track and field venue.
In addition to athletics and football, the London Stadium has also hosted baseball and rugby league matches, as well as motorsport’s 2015 Race of Champions.
The fixtures
Following Wednesday's trip to the East Midlands, West Ham welcome Championship high fliers West Bromwich Albion to London Stadium in the Emirates FA Cup Fourth Round on Saturday.
Then a home clash with Liverpool follows on Wednesday before Brighton & Hove Albion also visit the capital on Saturday 1 February before heading to Manchester City on Sunday 9 February.