The midweek clash will see both sides in the hunt for three points after suffering defeats over the weekend, with the Clarets losing out to Tottenham Hotspur and City suffering a 3-1 reverse to Arsenal.
Burnley and Leicester have already met once this campaign, in the latter's first home fixture of the season, with the hosts registering a 4-2 Premier League triumph on Filbert Way.
Since then, they have each contested a further 24 top-flight matches, with City heading into the match in third position in the division, while the Clarets occupy 15th.
Clarets forward Chris Wood netted 14 Premier League goals last term.
A number of players departed the Clarets over the summer with goalkeeper Joe Hart (Tottenham Hotspur), midfielder Jeff Hendrick (Newcastle United), winger Aaron Lennon (Kayserispor) and youngster Aiden O'Neill (Melbourne City), all leaving on free transfers following the expiry of their contracts.
In November, Burnley signed former Chelsea defender Richard Nartey, while in January, four key players - Matt Lowton, Kevin Long, Jóhann Berg Guðmundsson and Erik Pieters - all signed new deals at Turf Moor.
Across the 2019/20 season, former Fox Chris Wood was the Clarets' top goalscorer, notching 14 league goals in 29 games, and the New Zealand international also leads the way in the top flight this term, with four strikes. Jay Rodriguez, Matej Vydra and Ashley Barnes all have three to their name.
Only two Burnley players featured in every Premier League game last season - goalkeeper Nick Pope and centre-back James Tarkowski - with the former narrowly missing out on the Golden Glove award for most clean sheets.
This season, only Ashley Westwood has appeared in every Premier League match for Burnley, while England international Pope has missed just one game.
Sean Dyche is the longest serving manager in the Premier League having been appointed in October 2012.
Sean Dyche is the Premier League's longest serving manager and is approaching eight years at the helm of the Lancashire outfit, having been appointed on 30 October, 2012.
Succeeding Eddie Howe in the hot seat, Dyche guided Burnley to Premier League promotion in his first full season in charge (2013/14), and after relegation the following campaign, bounced back immediately, winning the Championship title in 2015/16.
In both promotion campaigns, Burnley equalled their highest ever points tally (93), before securing top flight survival via a 16th place finish in 2016/17. The following season saw the Clarets finish seventh - their highest-ever Premier League position - and qualify for the UEFA Europa League.
Although they failed to make the group stage of the competition, it marked a return to European football for the first time in 51 years.
In the league, Dyche's men were competitive again during 2018/19, finishing 15th on 40 points, while last season proved to be another successful campaign in which Burnley flirted with the European places before eventually finishing 10th.
Dyche, a centre-back by trade, started his career at Nottingham Forest in the late 1980s, before making his name at Chesterfield, where he enjoyed a seven-year spell, playing over 200 games. The Yorkshire side reached the FA Cup Semi-Finals in 1997, led by Dyche, who was captain.
His move to Bristol City also proved a successful one, helping the club gain promotion to the First Division in 1998, a feat he repeated at Millwall in 2001.
Spells at Luton Town (on loan) and Watford followed, ahead of a transfer to Northampton Town, where his playing career ended a season after the Cobblers' promotion from League 2 in 2006.
After hanging up his boots, Dyche managed his former club Watford, but despite an 11th place finish in his only season in charge - the Hornets' best league position for four years - he departed, joining Burnley a few months later.
Burnley's most recent outing saw them slip to a 4-0 loss away to Tottenham Hotspur on Sunday.
Burnley have notched up seven Premier League wins in 2020/21, with their latest coming in the form of a 3-0 triumph at Selhurst Park over Crystal Palace.
The Clarets' first victory in five outings across all competitions came courtesy of first-half strikes from Jóhann Berg Guðmundsson and Jay Rodriguez, before Matthew Lowton added a third after the break.
Since then, Sean Dyche's side drew back-to-back games with Fulham (1-1) and West Bromwich Albion (0-0) prior to Sunday's 4-0 loss to Tottenham Hotspur in the capital.
A brace from Real Madrid loanee Gareth Bale, and efforts from Harry Kane and Lucas Moura in the opening 45 minutes saw Burnley suffer their 12th loss of the current Premier League term.
Jamie Vardy celebrates as Erik Pieters' own goal makes it 2-1 during the 4-2 success in September.
Leicester's last clash with Burnley at Turf Moor ended in a 2-1 loss as second-half goals from Chris Wood and Ashley Westwood handed the Clarets victory in January 2020, despite Burnley-born Harvey Barnes' fine first-half opener.
The Foxes have won 12 of the 24 most recent previous meetings between the two sides, with Burnley winning on eight occasions and five ending in a draw.
However, all three goalscorers on that day are set to miss Wednesday's match due to injury.
The Clarets won the Sky Bet Championship title in 2016.
Burnley twice lifted the First Division title, in 1920/21 and 1959/60, and have also finished runners-up on two occasions (1919/20 and 1961/62).
They have three Second Division titles to their name, coming in 1897/98, 1972/73 and mostly recently in 2015/16. Promotion to the top flight has also been gained a further four times in 1912/13, 1946/47, 2013/14 and via the play-offs in 2008/09.
Their sole Third and Fourth Division trophies were won in 1981/82 and 1991/92 respectively. Burnley were also promoted from the third tier as runners-up in 1999/00 and through the play-offs back in 1993/94.
The Clarets are one of five teams to have won all of the top four divisions in English football, alongside Wolverhampton Wanderers, Preston North End, Sheffield United and Portsmouth.
Success has also come in cup competitions, winning the FA Cup in 1914 and twice lifting the Charity Shield (in 1960 and 1973).
Turf Moor has been Burnley's home ground since 1883.
Burnley have played at Turf Moor since 1883, which replaced Calder Vale as their home ground. The adjacent cricket pitch has been used by Burnley Cricket Club since 1833.
It currently holds 21,944 spectators and consists of four stands - the James Hargreaves Stand, the Jimmy McIlroy Stand, the Bob Lord Stand, and the Cricket Field Stand, which houses both home and away fans.
It held an FA Cup Semi-Final between Huddersfield Town and Notts County in 1922 and an international British Home Championship fixture between England and Wales in 1927.
The highest attendance at the stadium came in 1924, when 54,755 turned out to watch Burnley face Huddersfield Town in the FA Cup Third Round.
The club's record average attendance is 33,621, from the 1947/48 First Division campaign.
Following Wednesday's match, the Clarets face clashes with Arsenal and Everton.
After the midweek trip to Turf Moor, City are again on the road in the Premier League, heading to Brighton & Hove Albion's AMEX Stadium on Saturday for an 8pm kick-off.
The Lancashire outfit's fixture schedule, meanwhile, sees them host Arsenal on Saturday in the league, before they head to Goodison Park to take on Everton a week later.
All times BST.
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