Following Latrell Humphrey-Ewers' own goal in the 42nd minute at the Berkshire club's training ground, Terell Pennant doubled City's lead in the 76th minute.
With an FA Youth Cup Fifth Round tie at Bolton Wanderers on Wednesday, another two goals before the final whistle sends them into that encounter full of confidence.
Sidnei Travares added his name to the scoresheet with four minutes remaining before another from Dempsey Arlott-John in added time.
City's youngsters sit seventh in the South division with 20 points from 13 matches, although they are just two points off fourth-placed Aston Villa.
Following Wednesday's cup tie at the University of Bolton Stadium (7pm GMT kick-off), the young Foxes head to Swansea City next Saturday (11am GMT kick-off).
City: Bosworth, D. Gyamfi, Husek (Pennant 45'), Kranthove, Thomas (c) (Arlott-John 87'), Flynn, Tavares, James (Ewing 64'), Elewa-Ikpakwu, J. Gyamfi, Russ
Subs not used: Stolarczyk, Fitzhugh
Goals: Humphrey-Ewer og 42, Pennant 76', Tavares 86', Arlott-John 90+2'
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