Following last weekend's comeback 4-4 draw at Norwich City, the young Foxes remain unbeaten in 2020 and strengthened their sixth-placed standing in the league with a fifth win of the season.
Kian Pennant opened the scoring inside just two minutes at the Club's training ground before older brother Terell doubled City's advantage before the half-hour mark.
A composed penalty from Dempsey Arlott-John, on the other hand, made it 3-0 to Leicester, but Alfie Anderson was able to pull one back for the Royals on the cusp of half-time.
However, the home side's intensity continued in the second period with Kian Pennant adding his second goal of the game to send City's youngsters four points clear of Reading in the table.
The Club's Under-18s side now have a two-week break until they are next in league action when they are due to visit Motspur Park to tackle Fulham on Saturday 25 January (12pm GMT kick-off).
The details...
City: Bosworth (c); Sams (Nelson 80'), Aisthorpe, Barrett, Ewing; Arlott-John, Loughlin, T. Pennant (Flynn 80'), Fitzhugh (McAteer 70'), Leathers; K. Pennant
Subs not used: Weeks, Marcal-Madivadua
Goals: K. Pennant 2', 50', T. Pennant 29', Arlott-John 42' pen