The young Foxes headed to Motspur Park having picked up four points from their opening two league matches of the new 2023/24 campaign.
Inside two minutes in London, City were in front through Kirsten Otchere, but it wasn’t long before Ma'kel Bogle-Campbell and Tom Olyott overturned that lead before half-time.
Leicester’s youngsters kept battling, however, with Reece Evans and then Will Lawrence scoring either side of another Fulham goal from Olyott to make it 3-3.
Heartbreak was just around the corner, though, as Olyott completed his hat-trick in the 88th minute to seal all three points for the Cottagers.
Crystal Palace is next up at home for the young Foxes on Saturday (11am BST kick-off). The side coached by Adam Barradell are currently seventh in PL U18 South.
The details...
City: Bousor, Dyke, Aluko, Ononaye, T. Thomas, Guevara, Neale, Donnelly, Toure, Evans, Otchere.
Subs: Adedeji, Evans, Lawrence, McNab, Page.
Goals: Otchere 2’, Evans 58’, Lawrence 78’.