Daniel Amartey, Ben Chilwell, Marc Albrighton, Andy King and Islam Slimani all start for the Foxes in place of Shinji Okazaki, Riyad Mahrez, Danny Simpson, Christian Fuchs and Wilfred Ndidi.
Simpson and Mahrez are named among the substitutes, as is young winger Bartosz Kapustka, who made his Leicester City debut at Goodison Park in the FA Cup earlier this season. Ndidi is rested as a precaution with a tight groin, but should recover for the trip to Madrid on Wednesday.
SUBS: Steklenburg, Barry, Valencia, Calvert-Lewin, Lookman, Kenny, Williams
CITY: Schmeichel (c), Amartey, Benalouane, Huth, Chilwell, Albrighton, King, Drinkwater, Gray, Slimani, Vardy
SUBS: Musa, Kapustka, Simpson, Zieler, Ulloa, Mahrez, Wasilewski