The draw for the round of 32 took place earlier this month, and sees the Foxes, who are full of confidence on the back of wins over Manchester United and Manchester City, handed a difficult test.
As an elite team at Under-21s level, City enter the competition at the round of 32 stage, while Leeds advanced courtesy of an emphatic 6-0 victory at home to Doncaster Rovers.
Last season City beat at this stage of the competition before succumbing to defeat away at Newcastle United.
However with momentum building after wins over both Manchester sides in their previous two games as well as a double header of European fixtures against later this month, they will be hoping to go even further in the competition this time around.
Ticket details for the match will be confirmed in due course.