The tie will be played at the Citizens' new City Football Academy Stadium, which opened earlier this month.
Steve Beaglehole's youngsters have already qualified for the quarter-finals of the competition after beating both Schalke and Benfica 2-0 in November, but will fight it out with Patrick Vieira's side for top spot in Group C.
Manchester City defeated Portuguese giants Benfica 3-1 in November and play German outfit Schalke in mid-January.
After a last week, the young Foxes next face West Ham United in the league on Monday 5 January at Rush Green.