With three wins in four games over the festive period, the Foxes had an excellent Christmas, so will it be four league wins in five for Claude Puel’s side?
Here are your tips for the big game, from your official betting partner Ladbrokes…
Match odds
Leicester have hit positive form in the league right now. They’re 19/20 favourites to down the Saints, having won 2-1 at St. Mary’s Stadium in August.
The Foxes came from behind to win that game, as they did against Man City last month. There’s 11/1 about Puel’s men producing another comeback.
And if you fancy a more dominant display, it’s 9/4 for Leicester in the Half-Time/Full-Time market.
Correct score and goals
Leicester have won from behind three times this season, and there’s 15/2 about a 2-1 home win. It’s 16/1 for City to defeat the Saints 3-1.
But it must be worth noting that six of the Foxes’ league wins this term have been either 1-0 or 2-0. With that in mind, there’s 6/1 about 1-0, 8s for a 2-0 win and 3/4 if you fancy under 2.5 goals.
Goalscorer odds
After being rested last weekend, Jamie Vardy springs back into action as first goalscorer favourite. Leicester’s No.9 is 13/5 to open the scoring with his fifth goal in his last eight league games.
Vardy is also the only player odds-on to net anytime at 19/20. James Maddison is 11/2 to score first and 21/10 anytime, while Demarai Gray is 17/2 to bag the opener.
But it was Harry Maguire who grabbed the winner when these sides met in August, and the England international is 16/1 to score the final goal once again.
Get a bit more...
If you’ve not already got a Ladbrokes account, we’ve got a cracking new customer offer for you.
Bet £10 and get £30 in free bets with code G30!*
Plus, you can win up to £100 cash this weekend with 1-2-Free!
And remember, you can select your own markets for tonight’s game with #GetAPrice.
Choose your player and stat combo and let us know on Twitter by tweeting @Ladbrokes with your request and #GetAPrice.
Odds correct at time of writing.