The Foxes, who will be backed by 600 supporters on the continent, lead Group C by the tightest of margins with just one berth available to four teams vying for automatic qualification into the Round of 16. Whoever ends up on top will head there, while the second-placed outfit go into a play-off round with UEFA Champions League sides in early 2022.
Whoever lands third, on the other hand, will compete in the inaugural UEFA Europa Conference League – the least Leicester can achieve on Thursday. Their opponents possess real European pedigree too. Luciano Spalletti's Napoli remain one of the favourites to win the competition outright. Like City, Gli Azzurri, who sit third both in Group C and in Serie A, need a positive result at Stadio Diego Armando Maradona.
While preoccupied with their own endeavours in Naples, both sides will also be monitoring events in Poland as Legia Warsaw entertain Spartak Moscow at the same time with the group stage reaching a thrilling climax.
On Wednesday morning, Brendan Rodgers and his side departed the United Kingdom bound for Italy, scheduled to land early afternoon. It was the first act of what promises to be an eventful day for the Foxes, who will travel to Napoli's home ground – an Italia 90 venue – for open training in the evening. Rodgers and a member of his squad will also address the international media at Stadio Diego Armando Maradona, previewing a clash which will determine City's fate on the European stage. Make sure to check back to LCFC.com over the coming 48 hours for exclusive access to the Club's trip.