Jamie Vardy returns to the side after illness and suspension to start up front alongside Ahmed Musa, who scored twice against the Toffees on Saturday, while Ndidi will make his Premier League debut after impressing in that same match.
Christian Fuchs also comes into the team, meaning Leonardo Ulloa, Demarai Gray and Danny Simpson miss out on the starting XI.
Schmeichel, Huth, Morgan (c), Fuchs, Chilwell, Albrighton, Mendy, Drinkwater, Ndidi, Musa, Vardy
SUBS: King, Kapustka, Simpson, Okazaki, Zieler, Gray, Wasilewski
CHELSEA: Courtois, Alonso, Kante, Hazard, Pedro, Moses, Matic, Willian, Cahill (c), Azpilicueta, Luiz
SUBS: Begovic, Ivanovic, Fabregas, Zouma, Loftus-Cheek, Batshuayi, Chalobah