Both sides have progressed through four rounds to reach the last four of the world's oldest cup competition and a potential meeting with either Chelsea or Manchester City in the showpiece. Ahead of the two Premier League sides facing off, LCFC.com provides a rundown of everything you need to know...
How can I watch the game?
The second semi-final is set to be broadcast live on BT Sport 1 HD and BT Sport Ultimate in the United Kingdom from 6pm on Sunday.
Who's starring on LCFC TV?
From 5pm on Sunday afternoon, the Matchday Live coverage is set to get underway on LCFC TV and @LCFC social media with Leicester City stalwarts Gerry Taggart and Tony Cottee alongside presenter Dan Bates in the studio.
The trio will be joined by Matt Elliott, who will be live from Wembley Stadium, to discuss, preview and debate the last four clash against the Saints.
Alongside commentator John Dunn, former Foxes captain Elliott will then talk through proceedings as they happen, with live LCFC Radio commentary beginning at approximately 6:20pm and available for Digital Members (free sign-up) to listen to on the dedicated LCFC.com Match Centre.
What's the officiating team?
The referee at Wembley Stadium will be Chris Kavanagh, assisted by Dan Cook and Sian Massey-Ellis, while David Coote has been appointed as the fourth official. Paul Tierney will oversee VAR (Video Assistant Referee), assisted by Adam Nunn.
When does everything happen?
The last four meeting will be the second time that the pair have faced off this campaign. Find all the important matchday timings below...
| Event | Time |
| Matchday Live begins on LCFC TV | 5pm |
| Team news confirmed on @LCFC social media | 5:30pm |
| BT Sport coverage commences* | 6pm |
| Commentary starts on LCFC Radio | 6:20pm |
| Kick-off | 6:30pm |
| Full-time | 8:15pm approx |
| Match of the Day: The FA Cup starts on BBC One* | 11pm |
| Highlights on LCFC TV & LCFC social media | 12pm (Monday) |
*UK only.
What happened last time?
Leicester earned all three Premier League points from the previous encounter with the Saints at King Power Stadium on 16 January, 2021.
The opener came via a superb pass from Youri Tielemans, spotting the run of James Maddison, who brushed off the attentions of Jack Stephens before firing the ball into the near top corner from an acute angle.
Tielemans also assisted Harvey Barnes' second, threading the ball through for the England winger to race onto and slot beyond Alex McCarthy in the closing stages to seal a 2-0 success.
When can I catch match highlights?
Matchday highlights will be available on LCFC.com from midday on Monday and can be accessed by Digital Members for free on the Club's official website (free sign-up), while short clips can also be found on Leicester City's official social media channels.
Please note that in the interests of safety, Leicester City’s fixtures will continue to be played behind closed doors. To ensure matches can still go ahead and to help control the spread of COVID-19, the Football Club kindly asks its supporters to continue to follow their team from home and not to gather at any stadia.
All times BST unless stated otherwise.