Leicester City can finish as high as eighth in the final standings, but require a win over Ralph Hasenhüttl’s south coast outfit to have a chance of doing so, while the Saints are set to end the campaign in 15th or 16th position.
Before this weekend’s encounter - a 4pm kick-off on Filbert Way - gets started, take a look at all the key information you need to know...
Who's starring on LCFC Radio?
From 2:30pm on Sunday, presenter Dan Bates and former Foxes star Matt Elliott will begin our Matchday Live show from the TV studio on Filbert Way. A 90-minute preview show will include expert analysis, interviews from the LCFC squad and confirmed team news from both camps ahead of kick-off.
Then, with 10 minutes to go, we'll hand over to John Dunn and another ex-City defender, Gerry Taggart, positioned in the pressbox for live and free commentary of the encounter. Supporters can find in-play coverage on the dedicated LCFC.com Match Centre.
Another half an hour of reaction and analysis will also be provided - with pre and post-match programming accessible on @LCFC social media - as our panel of guests provide their verdicts on the 2021/22 season as a whole.
What's the officiating team?
Jonathan Moss will be in charge of proceedings on Filbert Way, alongside assistants Marc Perry and Shaun Hudson. The fourth official is Leigh Doughty, while the VAR will be Graham Scott, assisted by Timothy Wood.
How can I watch the game?
The following global TV stations with house live coverage of the fixture from around the world...
| Country | Channel | Local time |
| Australia | Optus Sport | 2am (Monday) |
| Brazil | Star+ | 12pm |
| Canada | DAZN | 10am |
| China | iQIYI Sports | 11pm |
| Denmark | Viaplay | 4pm |
| Egypt | beIN Sports | 5pm |
| Greece | COSMOTE | 5pm |
| Hong Kong | NOW TV & NOW E | 3pm |
| India | Disney+ Hotstar | 8:30pm |
| Jamaica | RUSH | 10am |
| Japan | DAZN | 12am (Monday) |
| Mexico | Sky Mexico | 9am |
| New Zealand | Spark Sport | 4am (Monday) |
| Nigeria | SuperSport | 4pm |
| South Korea | SPO TV | 12am (Monday) |
| Spain | DAZN | 4pm |
| Thailand | True Visions | 10pm |
| United States | Peacock | 11am |
Can't see your country? Click HERE for full broadcast times.
What happened last time?
Nothing could separate the sides at St. Mary’s Stadium in December 2021. Jan Bednarek gave the hosts a lead inside three minutes, before Jonny Evans restored parity later in the half.
The Saints went back in front when Ché Adams found the net, but James Maddison ensured City would take home a share of the spoils from their latest south coast trip.
When does everything happen?
A handy guide of key events and their timings to help plan your matchday...
| Event | Time |
| Matchday Live begins on LCFC.com | 2:30pm |
| Team news confirmed on @LCFC social media | 3pm |
| Live commentary starts on LCFC Radio | 3:50pm (approx) |
| Kick-off | 4pm |
| Full-time | 5:50pm (approx) |
| Short highlights on LCFC.com | 7:50pm (approx) |
| Clips on @LCFC social media | 10pm |
| Match of the Day on BBC One* | 10:30pm |
| Extended highlights on LCFC.com | 12am (Monday) |
* United Kingdom only.
When can I catch match highlights?
A two-minute highlights package will be published for free for Digital Members (free sign-up) on LCFC TV, available to watch via the Club's official website from two hours after the full-time whistle.
Extended match highlights, meanwhile, are accessible on LCFC.com at midnight, while short match clips will be posted to Leicester City's official social media channels from 10pm on Sunday evening.
All times BST unless stated otherwise.